Reverend Eric Camden (Stephen Collins) and his wife Annie (Catherine Hicks) have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.
This year, Eric and Annie will find themselves with much less to handle as most of their family is out of the house and in pursuing their own dreams.
Matt and Sarah are away in New York; finally doctors and raising their newborn twin boys. A rekindled Mary and Carlos have also relocated back to New York with their son, little Charles Miguel, as well as their newborn twin daughters. Simon is finally away at a university this year after a rocky period last year when being engaged to Rose. Ruthie is also out of the house for the time being in Scotland on a student exchange program for the school semester.
Despite most of the family being gone, Eric and Annie are still there for their daughter, Lucy (Beverley Mitchell) and husband Kevin (George Stults) as they cope with the loss of their twins after Lucy had a miscarriage earlier in the year. At this point in their marriage, Lucy and Kevin have hit a rough patch and only time will tell if open wounds will be mended. Meanwhile, Lucy continues to be Sandy (Haylie Duff) and Martin's (Tyler Hoechlin) support via phone call as the couple determines on where their relationship stands together as well as raising their son together. Sandy is still heartbroken over her feelings of Simon not being recipricated back after she admitted it to Simon at his wedding, but Martin hopes to fill the void as the man she wants to be with for the rest of her life.
At the same time Eric and Annie continue to raise 8-year-olds, Sam and David (Lorenzo and Nikolas Brino) to the best of their abilities...which eventually leads to Eric homeschooling the boys this year.
Also, after many years of battling heart problems, Eric is stunned to find out his recent diagnosis on his heart condition. This leads him to hide his condition from the rest of the family, which eventually does blow up in his face.
Nonethelss, together or apart, the Camden family is connected always and forever as the heart of the true American family in 7th Heaven.
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