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Dr. Mitchell Grace takes up his residency at the Boston's mysterious All Souls hospital. There he tries to solve the mysterious deaths of six women and tries to prevent one of his patients from becoming the seventh.

An ambitious orthopedist, Dr Stefani Volette, tells Grace that she can cure Patrick's paraplegia if he undergoes a life-risking operation. Stefani collides with Ambrosyus on a controversial treatment for spinal injuries. Grace discovers a shocking secret from his past.

Dr. Grace and Dr. Cullen try to discover what is causing the strange visions of a biogenetics's son.

When a heroic South American political activist arrives carrying a mysterious and deadly blood disease, Mitch races to save his life, but discovers that the disease is not the only secret his patient is hiding. Meanwhile, Dr. Cullen attempts to help a homeless man recover his memory, triggering a shocking discovery.

A number of women in an athletics program start dying and Dr. Grace wants to get to the bottom of it before one of the atheletes he is treating suffers the same fate.