Any Day Now tells the story of a friendship between two successful women in Birmingham, Alabama. M.E. is a writer, wife, mother and grandmother; Rene is a single attorney who specializes in civil rights law. Through flashbacks in each episode, we see how their personalities and their friendship developed in the dawn of the Civil Rights Movement of the 1960s.

The show's theme song is "Any Day Now", which was written in the 1960s by Burt Bacharach and Bob Hilliard, and was a huge hit for Chuck Jackson, who recorded it in 1962. Lori Petty sings the version heard on the show.