Here are some general show, character trivia. Some are also in the episode guides:

- In a 1996 episode, the series quietly broke a major network TV taboo by showing the uncensored breasts of a teenage girl after her character undergoes successful reconstructive surgery. The scene, conducted with no fanfare and in good taste, attracted little controversy.

- Premiered on a Thursday in the US, the same night as "ER" (1994). "Hope" was trounced in the ratings and moved to another night. Actors Noah Wyle and Peter Berg appeared on each others shows in an uncredited or voice-over roles. In one storyline, "Hope" did a commercial that looked exactly like the opening credits to "ER."

- The first television show to be shown in HDTV in the USA.

- Mandy Patinkin portrayed his character Dr. Geiger in crossover appearances in both "Homicide: Life on the Street" (1993) and "Picket Fences" (1992).

Saint Elsewhere Trivia:
- St. Elsewhere co-starred Mark Harmon as Dr. Bobby Caldwell.
- Dr. Austin wins the "Left Anterior Descending Aorta" award for being a top notch cardiac surgeon - this was previously awarded to Dr. Craig on St. Elsewhere.
- Stephen Furst appeared playing a vet named Elliot. On St. Elsewhere he played Elliot Axelrod whose father was a vet (he did not appear as his actual St. Elsewhere character though as Elliot Axelrod, he was killed off in St. Elsewhere).
- Dr. Austin quotes her mentor to be "Dr. David Demidian." Mark Craig ('William Daniels' ) on St Elsewhere said that Demidian was his mentor as well.

Added it. I've never seen St Elsewhere before!

There are several recurring themes and storylines throughout the history of the series. This list may not be comprehensive. They include:

Threats to Athletes:

Episodes in this category have some gifted athlete whose career is threatened by illness or injury, which leads them to refuse medically necessary treatment or induces the doctors to come up with drastic and/or risky procedures to save their professional futures.

Season 1 Great White Hope

Season 2 Christmas Truce

Season 4 White Trash

Season 6 Vigilance and Care

Biohazards:

Examples of this includes highly contagious and deadly epidemics and terrorist attacks.

Season 1 The Quarantine

Season 2 Last One Out, Get the Lights

Season 6 White Rabbit

Gender Issues:

This explores issues of gender identity, gender expression, gender experiments, and intersexual condition.

Season 1 Informed Consent

Season 2 Right to Life

Season 2 Women on the Verge

Season 2 The Parent Rap

Season 6 Boys Will Be Girls

Marfan's Syndrome:

Patients with this somewhat unusual condition.

Season 1 Death Be Proud

Season 6 Team Play

Season 6 Simon Sez

Religious Objections:

Patients refuse or modify the recommended treatment because of it.

Season 1 You Gotta Have Heart

Season 2 The Parent Rap

Season 5 Viagra-Vated Assault

Season 6 Hanlon's Choice

Violence Breaks Out in the ER:

Season 1 Shutt Down

Season 1 Life Support

Season 2 Quiet Riot

Operating on Fetuses:

Season 2 From Soup to Nuts

Season 4 Risky Business

Season 6 Miller Time

Dead Fathers:

Women trying to become pregnant after their husbands had died.

Season 2 Rise From the Dead

Season 6 Upstairs, Downstairs

Advice to Abort:

Abortion is a very touchy subject throughout the series. It often isn't brought up as a medical alternative even in appropriate circumstances. These are examples of when it is brought up, but is rejected in every instance.

Season 3 Higher Powers

Season 5 Kiss of Death

Season 6 Miller Time

Absent Organ:

These are instances that for a variety of reasons that transplants are planned or even begun, but there isn't an organ to transplant. This doesn't include the usual circumstance of being on a waiting list and there isn't an organ available.

Season 3 A Day in the Life

Season 5 Home Is Where the Heartache Is

Season 6 The Heart to Heart

Season 6 Gray Matters

Miracles:

Instances of unexplainable cures or illnesses.

Season 3 Hope Against Hope

Season 4 Memento Mori

Season 6 Faith, Hope, and Surgery

If any of you Chicago Hope-lovers are still around: I have a question for you.

In one of the most recent NCIS-eps Rocky Caroll is introduced as NCIS assistent director. He also worked with Mark Harmon on Chicago Hope as doctor Keith Wilkes. Now on NCIS when they first shake hands, Gibbs (MH) receives 2 dollar something from Leon Vance (RC), saying that settles something that happend 8 years ago. This may be an allusion to the time they worked together at Chicago Hope. Does anyone remember something like that? Thanks for many answer!