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The series begins when 18-year-old George Lass is killed by a toilet seat from the Mir space station hurtling towards earth. She discovers that the afterlife does indeed exist, where she has been assigned a job as a 'Grim Reaper.' It's her job to reap the souls from the living and guide them to their eternal reward. Besides coping with her new job, she must learn to deal with being young and starting out - and of course, being dead.

New reaper George tries to avoid having to take souls. Mason steals money from parking meters. Reggie steals toilet seats from school and neighborhood.

George continues to visit her home to check up on her parents, until she discovers the price to pay for doing what she has been forbidden. Meanwhile, at the Lass' home, the family prepares to have their picture taken.

George finds a loophole in the "reaper rules" and decides to spare her next soul, but quickly learns that if you flip off Fate, Fate flings it back at you ten-fold.

George spends some time with Betty and realizes that she actually found a real friend, but soon as she becomes happy, Betty decides to take a one-time chance and go to the other side. Meanwhile, Mason reaps an old woman and spends some time with her.

George is devastated after losing Betty and gets even more depressed when a new reaper called Daisy Adair arrives to take her place. Meanwhile, George is put on the Happy Time bowling team and we see a caring side to George as well as a competitive side to Delores.

George has her first affair in the afterlife with a living schizophrenic, Ronnie Dobbs, whose disease allows him to see gravelings. Clancy and Joy are arguing about sending Reggie to a public school.

After George brings home a dog left behind by one of her assignments, her life suddenly gets considerably more complicated. Meanwhile, Rube takes a job as a short order cook at Der Waffle Haus, after he reaps the main chef.

Mason rescues a college student Charlotte from a date rape and she becomes fast friends with George. However, their friendship might be at stake when George realizes that Charlotte is enamored with her English Professor, who turns out to be George's father, Clancy. Meanwhile, Roxy takes desperate actions to stop a renegade from acting badly, but that might just turn and hit her in the back.

Daisy recruits George and Mason for a money-making-scheme using the ghost of a rich lady. Meanwhile, Roxy is having troubles dealing with the anniversary of her death and Rube is there to help her.

George wants to buy a bicycle and decides to quit her job at Happy Time and move on to a new one that a fellow partner found for her. This causes a big celebration party for her, where Delores is everything but happy. Meanwhile, Daisy wants to steal a picture from a dead painter, so he won't go away until he is assured that Daisy won't take it away.

It's time for annual evaluations for the Reapers. Meanwhile, George is desperate to know whose name is on Rube's post-it, for the address is that of her family's house.

When death takes a holiday and no one is supposed to die, the team has a completely different task - they have to do paperwork for all the people reaped by Rube's division and George has a brilliant idea to make a long-process finish earlier. Daisy and Mason get closer, while the Lass family goes on an annual vacations by the lake.