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Series Finale: ER ends its 15 year run with a two hour episode. Gates works on a young teen suffering from alcohol poisoning after playing a drinking game. Old friends come show their support when a new medical facility for the underprivileged is opened. Sam receives a special gift for her birthday. Carter and a new intern try to save a mother in labor with twins.
Doctors and nurses from the ER help out at a camp for children who have had open heart surgeries. A woman returns to County for the baby she previously abandoned there.
Neela proves her worth as attending material when she clashes with Dubenko on how to proceed with two different surgical cases. Brenner gains a deep insight into his painful childhood.
A former mentor and colleague visits Carter in his time of need as he waits for a kidney transplant. Meanwhile, a woman is grief-stricken over the sudden death of her grandson. Sam and Neela are stuck at the airport with transplant organs in hand. Banfield bonds with a baby abandoned at the ER.
A camera crew shooting footage for a documentary interviews members of the ER staff. Detective Claudia Diaz is brought in, critically injured with gunshot wounds. Neela laments the lack of communication between her and Brenner. Sam struggles to reconcile with her mother. Carter's condition worsens quite suddenly.
The Banfields explore their options with an adoption agency. Carter holds his own in spite of the procedural and technological advances made to emergency medicine since he's been gone. Brenner has concerns about Lucy's foster family. Morris treats a couple who takes his advice a little too far. Sam gets quite the shock when her mother comes into the ER. Neela makes a decision about her future. Banfield discovers Carter's secret.
Valentine's Day in the ER finds Neela spellbound by Brenner. Determined to have a baby, Banfield comes up with a plan but has difficulty getting her husband on board. Neela performs surgery on a young girl's mother. Dr. Carter surprises the staff with a visit to the ER. Gates treats a strange patient who may have ingested a toxin while hunting for mushrooms.
A car accident in the ambulance bay injures a woman with a young child and leaves the mother in need of surgery with a significant recovery time. Brenner has difficulty finding a family member to care for the daughter. Gates treats an elderly patient who refuses treatment because he's afraid his condition will prolong an inevitable death. Morris impresses Claudia and her family. Neela tells Brenner about her job offer from North Carolina.
Gates and Morris tend to an elderly man who was assaulted on the street. Sam's sister shows up unexpectedly. Brenner and Dubenko clash while treating a mother thought to have late stage cancer. Dr. Morgenstern returns to the ER to assist a former mentor who is seriously ill.
Morris faces a complicated case involving a young girl hit while riding her bicycle. Gates finds it very difficult to let go of his feelings for Sam. Neela becomes quite flustered when Brenner returns from Australia.
Neela has recurring dreams about trying to save a girl with sickle cell anemia. In them she also goes to an attending interview and sees an old colleague, has conversations with Ray, welcomes Brenner back from Australia, and assists Gates and Banfield in trying to save a "dream runner" who jumped out of a window during his sleep.
When a drug deal goes bad, two brothers sustain serious injuries and are brought to the ER. Tensions continue between Gates and Sam, coming to a head when Tony is the last to know Alex is about to be released from the hospital. Neela has to tell a young girl with sickle cell anemia that she must have an operation, and the case leads her to consider specializing in pediatric surgery. A feisty patient takes Morris into her confidence. Banfield ponders her choices about expanding her family.
A package for Morris from his deceased father is delivered to the ER. Sam has some anxiety over Alex being removed from the ventilator. A woman with a high risk pregnancy worries that she will be deported. An old friend returns to celebrate the holidays.
Neela must testify in court and defend her actions regarding a patient who died. Sarah and Alex defy Sam and sneak off to a party, with dire consequences. A snowstorm strands Banfield and Morris at a Nebraska medical conference.
Gates goes out looking for a homeless war hero and upsets Sam. Neela's med student gets the entire surgical department into a lawsuit. A couple comes into the ER after an attempt was made at burning down their home. Brenner gets into a fight with a patient, and later confesses a secret to Morris.
While out for a mind-clearing run, Banfield encounters a desperate situation and finds herself trying to rescue a very young girl from drowning in a nearby lake. Painful memories of her son in mortal danger and Dr. Greene's heroic attempts to save him are triggered during the experience. Meanwhile, Gates attempts to pull some strings to help out a homeless war veteran, and the interns continue to struggle in the ER.
Chaz, now a med student, begins his ER rotation. Morris takes him under his wing and shows him some risky procedures, endangering a patient and raising Banfield's ire. Neela becomes upset when Banfield questions her authority and skills in front of her intern. Gates invites Sam and Alex to move in with him and Sarah.
It's Halloween night, and the interns continue to be paired with the residents. Gates' teaching methods with Daria, and her responses, belittle Sam. A school fight results in a stabbing and a nose that won't stop bleeding, with Brenner treating the victims and being deeply affected by the truth behind their confrontation. The staff, especially Neela, are enthusiastic about a surprise visitor. Gates gets locked in a maintenance area with a quiet young boy.
Dr. Banfield defends herself ably during a mugging. Dubenko returns to work, due in no small part to Brenner's organized protests. In return, Brenner asks a favor of Dubenko. A young gymnast comes into the ER with injuries consistent with a fall, but Banfield and Gates each think a different family member may actually be to blame. Sarah neglects to ask Gates' permission before getting her tongue pierced.
Abby's first day as an Attending is bittersweet. Neela is hurt when she finds out Abby's news from someone else. Abby and the new ER Chief argue over how to treat a gunshot victim. Abby comes to Sam's aid when she faces a nurses' disciplinary board.
Everyone in the ER is trying to cope with the loss of their colleague. The staff feels defensive toward the new Chief and her tough disposition. Gates and the new interns treat a bio terrorist, who has a lethal secret that endangers them all. Neela makes a great effort to get Dubenko back on the surgery staff, and gets help from an unexpected souce.
Season Premiere: The 15th and final season of ER begins with the devastating repercussions of the ambulance explosion. As Morris and Neela do everything they can to save a wounded colleague, Abby treats a young girl injured during the blast.
One hour of memorable clips from past episodes, as well as interviews with current and former cast members.
