An eighteen-year-old girl wants Andy to check her for the breast cancer gene, as it runs in her family. The girl and her older sister (who already had cancer and a double mastectomy) go see Andy for the results. After being tested positive, they decided to have a preventative mastectomy to lessen the chance of cancer. Bright and Hannah are out on a date when something happens to both of them, and they call Harold.

Ephram talks Kyle into accepting an invitation from a pretty classmate to go to a school dance, but when Kyle has a terrible evening, Ephram finally faces his suspicions that Kyle may be gay. Feeling that he has made things worse for Kyle, Ephram turns to Amy and Andy for advice. Kyle doesn't want lessons from Ephram any more, again.