Writer:	Joe Keenan, Christopher Lloyd (II)
Director:	David Lee
Star:	Kelsey Grammer (Dr. Frasier Crane),  Moose (Eddie),  Jane Leeves (Daphne Moon Crane),  David Hyde Pierce (Dr. Niles Crane),  Peri Gilpin (Roz Doyle),  John Mahoney (Martin Crane)
Recurring Role:	Edward Hibbert (Gil Chesterton),  Patrick Kerr (Noel Shempsky),  Tom McGowan (Kenny Daly),  Harriet Sansom Harris (Bebe Glazer),  Anthony LaPaglia (Simon Moon),  Wendie Malick (Ronee Lawrence Crane)
Guest Star:	Chris Marcil (Steve Glazer),  Arleen Sorkin (Rachel),  Cleto Augusto (Moving Man),  Mark Deklin (Clint),  Marc Wilson (Paramedic Rob)

In the scene at Cafe Nervosa when Roz reveals that she is the new station manager, writer/producers Bob Daily, Lori Kirkland Baker, Jon Sherman and Heide Perlman can be seen as coffee-sipping patrons in the background.
(edit) In the scene at the vets, the cat owner is played by Jeff Greenberg who was the shows casting director. His cat was called Saladin named after writer Saladin K Patterson.
(edit) In the scene where Frasier gives his farewell speech on KACL, behind him through the glass can be seen creators David Lee and Peter Casey as well as writers Joe Keenan and Christopher Lloyd and editor Ron Volk (edit) With a final total of ten appearances, this episode earns Harriet Sansom Harris the "bronze medal" for third place among recurring characters, placing her behind Luck Hari (11) and Edward Hibbert (12).
(edit) At the 2004 Emmy Awards, Kelsey Grammer won the Emmy for Outstanding Lead Actor in a Comedy Series for his performance in the episode "The Doctor is Out". In addition David Hyde Pierce won the Emmy for Outstanding Supporting Actor in a Comedy Series for his performances in the episodes "No Sex Please, We're Skittish" and "Goodnight, Seattle (2)". The show was also nominated for Outstanding Casting for a Comedy Series. (edit)

Bebe: Frasier! It's done. When destiny calls, Bebe calls back and screws destiny to the wall. (edit) Niles: I'll miss the coffees. (edit) (Frasier's final farewell to his listeners on KACL after reading Ulysses.)
Frasier: I've been thinking about that poem a lot lately. And I think what it says is that, while it's tempting to play it safe, the more we're willing to risk, the more alive we are. In the end, what we regret most are the chances we never took. And I hope that explains a little this journey on which I'm about to embark. I have loved every minute with my KACL family and all of you. For eleven years you have heard me say, 'I'm listening.' Well, you were listening too. And for that I am eternally grateful. Goodnight, Seattle. (edit) (Last line of the series.)
Frasier: Wish me luck. (edit) Frasier: When I go through that Golden Gate, I'll be smiling.
Martin: Golden Gate?
Frasier: Yes, in San Francisco. I'm moving to San Francisco. Now I know this is a hard time to accept, so let it all out.
(Everyone laughs, after thinking that Frasier was dying)
(edit)

While gathered together on Frasier's balcony, Martin, Frasier, and Niles are talking. Frasier mentions "It's just an hour by plane" (between San Francisco and Seattle). Most commercial flights run in the two hour to two and a half hour range between those two cities. (edit) The poem Frasier quotes in this episode is Alfred Lord Tennyson's Ulysses.
(edit) John Mahoney was 63 when this episode aired. The character Martin, on the other hand, is pushing 72 (he turned 65 in Season Five's "The Gift Horse"). (edit) In "Don't Go Breaking My Heart (3)" in the flash-forward to Niles' and Daphne's second child's birth, Niles is holding a girl. In this episode, Daphne gave birth to a boy. (edit) When the moving man takes Martin's chair away, it squeezes through the front door on its way out; but when the delivery man brought the chair into Frasier's apartment in the pilot, it didn't squeeze through the door, it came in easily. It is a different chair, but they're supposed to be identical. (edit)

Frasier: "... To strive, to seek, to find and not to yield."
Frasier's farewell to Seattle are the last nine lines of Lord Alfred Tennyson's poem "Ulysses." (edit)