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A woman in an office, Megan Bradberry, is talking to her boyfriend Ben on the phone and she declines to go to Star Wars with him. He calls back from the parking lot to apologize, and she complains of wooziness, but the building collapses as he looks on.

Cuddy tries to get House interested in Megan’s case as she’s displaying further symptoms after being dug out of the rubble. She also wants him to hire a new team, but he refuses. House is more interested in playing his guitar and offers Cuddy a deal: if he can diagnose the girl by end of day, she leaves him alone for a week. She agrees, although Wilson has her doubts. House ends up recruiting the janitor to help him and after meeting with Megan, House offers to pay him to break into her house to check things out.

House takes Wilson to Megan’s house after tricking him with a lunch invitation. They search the house and House finds her secret diary. It turns out Megan was depressed until recently, and he suspects medication that her boyfriend and mother didn’t know. House has the janitor ask them to sign the release forms for dialysis treatment, and the janitor lets slip he’s not a doctor. They go to Cuddy, and House manages to convince them they might not know enough about Megan to be sure she wasn’t taking anti-depressants.

House goes to his office only to find his guitar missing. He quickly figures out Wilson has kidnapped it, and Wilson insists he interview for his new team, but House points out he’s solved the case. Cuddy tries to get through to Megan to find out what medication she was on but the girl has a heart seizure.

Cuddy confronts House to note he lost his bet and he suckers into her helping on the differential. He then goes to Wilson and agrees to review the resumes, but Wilson keeps the guitar until the interviews are done. House goes back to find Cuddy hasn’t come up with anything, and suspects Megan has heart damage brought on by the collapse. They test her heart and it’s fine, but her fever is back and House concludes she’s in DTs. Ben and Megan’s mother insist Megan couldn’t have been taking drugs or alcohol. House proposes they give her alcohol and then taper her off, and it becomes clear Ben and Megan’s mother aren’t on good terms. However, Mrs. Bradberry agrees to the treatment.

That night, House calls his first less-then-impressive applicant for an interview then pages Wilson to the hospital while he searches Wilson’s hotel room for the guitar. House erases Wilson’s Tivo in revenge, escalating the situation.

Megan starts to recover but they notice she’s unconscious but moving her mouth. Cuddy realizes that she’s silently screaming. She confronts House with the fact his differential was wrong but refuses to discuss the matter further with him. House goes back to differential… with his magic eight-ball. Cuddy interrupts, refusing to let Megan die, but House discovers Wilson is starting to break apart his guitar. Wilson wonders why House is reluctant to hire a team while he goes over Megan’s tests, and suggests he might be gunshy of being hurt. House has determined that Megan is going to start internal bleeding and orders her into surgery. Cuddy reluctantly enters into differential but argues that House needs a team, but he notices the size of Megan’s uterus. Going into the operation room, he realizes she was recently pregnant and had an abortion before Ben found out about it. He goes to talk to Ben, who is with the boyfriend of her co-worker Liz who died in the collapse. House reveals that Megan was on the pill, which caused the symptoms. Ben doesn’t believe Megan had the abortion but the blood tests are conclusive, and it caused the bleeding. Ben grants him permission to administer an anti-cancer treatment.

Later House goes to see one of Wilson’s patients, San Lee… and moves him to a different room to convince Wilson he’s been kidnapped. He goes to see Megan… who is collapsing from the treatment, even though House insists he isn’t wrong.

Desperate for someone to talk to, House goes down to the ER but Cuddy has told everyone not to talk to him. One doctor finally offers to help and suggest crush syndrome, and refuses to acknowledge it might be a combination of symptoms that can’t be cured. House suggests she give him her resume and then goes to see Megan. Ben and Megan’s mother are there and House informs them Megan’s body is giving up and all they can do is maintain her with supportive dialysis. He notices a lump on her arm and orders a biopsy, overriding Cuddy’s orders to the lab technician. Megan has multiple growths, granulomas that signify an allergic reaction. Cuddy puts Megan on steroids but they don’t know what she’s allergic to.

House is left to consider the white board while Wilson realizes his patient has disappeared and confronts House. Wilson is concerned she gets the wrong meds which strikes a chord in House. He gives Wilson Sam’s room number then goes to wake up Megan, pointing out that she’s been lying about everything, but her lies can’t account for the allergy. House realizes that Megan isn’t Megan: it’s her similarly-looking co-worker Liz, and Megan died. Ben mistakenly identified the surviving Liz as his dead girlfriend Megan.

Ben and Mrs. Bradberry are left to mourn, while Cuddy points out that Cameron, Foreman, and Chase would have solved the case days ago. She insists he hire a team and starts interviewing a room full of applicants… while playing his recovered guitar.