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Actor Evan Greer is filming a scene for his soap opera as Dr. Brock Serling, and suddenly collapses. It's all part of the script but Evan insists the entire thing is garbage. Greer leaves in his towncar but the driver takes him in the wrong direction. The driver then locks the car doors and introduces himself as… Dr. Gregory House, who plans to save Evan's life.

House arrives at the hospital where Cuddy is waiting with the accreditation on-site inspector. She hastily denies knowing House, who notes Evan that he is having trouble reading his lines, which makes House thinks he has a brain tumor. He convinces Evan to undergo a vision test. Meanwhile, Cuddy asks the staff to make sure and behave for the inspector, and then asks Chase, Foreman, and Cameron to watch House. Chase refuses and Foreman agrees to watch House while Cameron finishes is paperwork.

House is testing Evan and claims he's spotted something but Foreman comes in and realizes the test is proving negative. Evan leaves and House goes out, where he runs into Wilson who is having back troubles because he's having trouble with Amber's mattress. House warns that Amber will turn it into a game that she will insist on winning. While talking, House and Wilson end up in the elevator with Evan, and House drugs him and takes him to the MRI test chamber. However, the MRI tests also prove negative for tumors as well. Evan storms off and House has Taub and Thirteen try and convince him not to sue. However, when Evan gets to the lobby he collapses due to a numb foot.

It's into differential where Cameron suggests a series of tests while trying to finish House's paperwork. House doesn't believe her tests will prove useful but Kutner goes ahead and does them, while Evan says he's rather do something inspiring. Meanwhile, House watches the soap with the rest of the team on high-def TV to look for signs of illness. Cuddy comes in and talks to House about behaving during the accreditation: he bargains for the high-def TV. Before Cuddy can respond, Kutner reports the foot numbness is a real symptom but doesn't show any toxins, and House still believes it's the result of a toxin and sends Kutner to check out Evan's home while he goes to Evan's dressing room.

Wilson and Amber are buying mattresses and Amber tries to get the salesman to knock down the price by lying that she's pregnant and has been laid off. However, she relents and lets Wilson pick whatever mattress he wants, hard or soft. Wilson calls House at Evan's dressing room to let him know Amber is letting him choose, but House thinks she's manipulating him. House notices flowers, gin bottles, and sunflower seeds, but not toxins, then talks to Evan's co-star, who notes they dated once but he didn't do anything. House concludes Evan is impotent based on the sunflower seeds in his dressing room, and the sunflower seeds are the toxin, leaving B6 in his blood. They put him in the sleep lab and test him for sexual arousal: they confirm he isn't impotent but then Evan goes into cardiac arrest.

In differential, Cameron suggests hyperthyroidism and House now believes the thyroid is responsible. Cameron keeps interjecting, and House suspects she wants to be back on the diagnostic team. Foreman finally agrees with House that they should nuke Evan's thyroid, startling everyone. However, once they're outside, Foreman reveals to the rest of the team they're going to just do iodine uptake testing and by the time House finds out, they'll know one way or another.

House is in the morgue having a snack when Cuddy finds him there, just ahead of the inspector, Conway. House figures Cuddy hastily hides the food and Conway ends up wondering if they're having an affair. Cuddy caves and House gets his HD TV and Cameron comes in to announce the paperwork is done. House figures that she misses him and she thinks he hired Thirteen because he couldn't get her. She admits she misses the puzzles and the investigation, and he offers to fire Thirteen or Kutner to get her back. However, she also admits she doesn't miss House.

During the iodine testing, Taub finds it hard to believe that Evan doesn't find his work meaningless. However, they run the test and although Evan's thyroid is normal, they discover the iodine is spread throughout Evan's body: his kidneys are failing. House isn't thrilled they failed to destroy the thyroid, despite the fact that doing so probably would have killed Evan. House accuses Foreman of going behind his back to make sure they passed the inspection, but Taub is more concerned about the patient, saying it could be auto immune. House counters by telling the team to make sure that everything is within height compliance.

Wilson and Amber end up on their new mattress but Amber freezes up when she realizes he bought the firm mattress. She's upset that he got the mattress she wanted instead of the one he wanted, and accuses him of resenting all of his ex-wives because he did what they wanted. She notes she doesn't need him to take care of her, and wants him to take care of himself.

House visits Evan who still wants to do something that matters. House notes that nothing matters and tells him to quit if he's unhappy. Evan says he can't and wonders if House is afraid of change. House figure Evan is afraid of failure so he won't try, and Evan says he'll use his second chance to set things right. However, Evan then starts deliriously reciting lines from the last season of his soap opera. His temperature goes up and House calls in cooling blankets as Evan asserts he's his soap opera character.

Now that Evan is septic with an infection and in a coma, they need to target the specific cause. Foreman suspects a fungus or parasite but House goes to relax on a mattress and help Wilson shop for his new bed. Wilson announces he's wanted a waterbed all his life but then tries to back out of it. House is more interested in the flower design on the beds and takes off.

House meets with the team and announces Evan has an allergy. The fungus and parasite tests have proven negative and House notes there were chrysanthemums in Evan's dressing room, which are a known allergen. House decides to administer steroids, despite the fact it will kill Evan if it's an infection. When the hospital pharmacist is reluctant to hand out a massive dose of steroids, House barges in and takes the steroids, then goes to Evan's room. Cuddy intervenes and insists that House wait for the blood tests. She finally admits her job and House's are on the line, and he tells her to call security in three minutes, covering her and letting Evan live. Cuddy backs down and lets House administer the steroids.

As the staff wait, Cuddy reports that the tests prove negative for floral allergies and goes to reorder the antibiotic treatments. However, when she gets to Evan's room she finds out that Evan is recovering: it was an allergy after all. House notes that he was wrong and they should have stopped him. Conway confronts Cuddy, noting that House was wrong and he broke the rules.

Amber wakes up and discovers Wilson is sleeping on the floor in the next room: he hates the water bed and can't sleep on it. Amber assures him they'll take it back.

House is watching his soap opera again and notices Evan drinking on set. He calls Cuddy, who reveals they got a $200,000 fine. House says that there was quinine in the water: he spotted bubbles in the liquid and Evan is allergic to quinine. Brock was drinking gin and tonics, and while the gin was fake, the tonic had quinine in it. Cuddy insists on taking back the TV and wishes him good night.