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It's a day in the life of Cuddy when she has to deal with her personal and professional life, insurance contract negotiations, a thieving pharmaceutical technician, an ailing daughter, and House and his team.
The team disagree on how to treat a college football player who wants to be cured in time to compete in the NFL tryouts. Meanwhile, Foreman's brother Marcus pays him a visit.
House decides to take on the case of a beautiful female executive based on her looks, and the other males on the team are equally smitten. Only Thirteen is able to remain unaffected as they try to determine the cause of the woman's illness. Meanwhile, House tries to resolve his past with a former medical school colleague he wronged
A drug dealer collapses during a sale, but refuses to reveal personal information to the team because it might incriminate him. Meanwhile, Foreman's teammates conspire to play a practical joke on him, while House and Wilson both aim their sights on an attractive new neighbor, Nora.
Wilson insists on treating the case of a friend and former patient, Tucker, who is suffering from paralysis of his right arm. However, he soon discovers that he can't separate his feelings from his professional attitude. Meanwhile, Cuddy tries to buy a new house.
It's Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier.
House is finally reinstated and takes on the case of a porn star with eye pain. Meanwhile, Chase and Cameron try to resolve their relationship issues after Chase's admission, and House tries to bring back Taub and Thirteen.
House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.
A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.
A rich businessman brings his son, who's suffering from stomach pain, to Princeton Plainsboro, and believes he's a victim of his wealthy position and success.
House's team struggles with an African politician who falls ill and decide if they want to help him after he's charged for crimes against humanity in his country.
House returns to Princeton Plainsboro, announcing he will make big changes in his life. Meanwhile, House's team can't diagnose a new patient who's obsessed with posting each and every one of his symptoms over the Internet.
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House engages in a battle of wits and wills against the attending physician in charge of his detox program. When he starts to lose, House resorts to blackmail to gain the upper hand.
