Star:	Gary Cole (Mr. Dr. Possible),  Nicole Sullivan (Shego),  Raven-Symone (Monique),  Grey DeLisle (Hana Stoppable),  Jean Smart (Mrs. Dr. Possible),  Christy Carlson Romano (Kim Possible),  Will Friedle (Ron Stoppable),  John DiMaggio (Dr. Drakken),  Patrick Warburton (Mr. Barkin),  Nancy Cartwright (Rufus),  Tahj Mowry (Wade),  Spencer Fox (Jim and Tim Possible ( Season 4))
Recurring Role:	Kirsten Storms (Bonnie Rockwaller)
Guest Star:	Brian George (Duff Killigan, Professor Ramesh),  Jason Marsden (Felix Renton),  April Winchell (Reporter),  Gedde Watanabe (Professor Bob Chen),  Debbie Reynolds (Nana Possible),  Kevin Michael Richardson (Slim Possible),  Kirsten Johnson (Warmonga),  George Takei (Sensei),  Ron Perlman (Warhok)

This episode aired on Toon Disney's Most Impossible Kim Possible Marathon on April 12th, 2008. (edit) The final two episodes of season four aired on Disney Channel Australia on February 1st, 2008 as a part of a Kim Possible double episode special. (edit) This episode's premiere was ecliped by a 54-hour megathon on Disney Channel in which every single episode and movie in the series was shown. (edit)

(After Drakken is drenched in his Pollinator mutagen)
Kim: (about Drakken) He's mutating!
Shego: This is new.
Ron: He's...He's...
(Drakken emerges from the shadows)
Ron: He's a pansy?
Kim: Um, I'd say marigold.
(Drakken looks at his reflection)
Drakken: What?! I look like a kid playing a flower in a school play! All I want is one clear-cut victory. Is that too much to ask? Is it?! (edit) Shego: You know, I could have stolen something actually dangerous, but no, no. You had to be "creative".
Drakken: This time, I win, Shego. I'm due. It's my turn. One blast and zowie!
Shego: And "zowie" is good?
Drakken: "Zowie" is zowie, Shego. It's better than good. It's bad! (edit) Drakken: With this Super High Pollinator - of my own design, I will create my own army of...
Shego: ...killer plants?
Drakken: Are you guessing, or did you just look at my notes?
(He holds up a doodle of himself and a giant plant) (edit) Kim: Do you realize we're actually leaving a lair intact for once?
Ron: Yeah, I know. I kinda miss the explosion. (edit) (The power goes out just as the final bell for the seniors is about to ring)
Mr. Barkin: Well that was anticlimatic.
(He makes a ringing noise as the seniors file out)
Mr. Barkin: Oh, every year! It's like opening a barrel of rabid monkeys! (edit)

At the school, Barkin tells Ron, "The center cannot hold." In Ron's memory, Barkin's words are "The center will not hold." (edit) When Ron was feeding and watering the animals at Smarty-Mart, he was whistling the theme to the Naked Mole Rap. (edit) Kim and Ron kiss twice in this episode. The first time was at Bueno Nacho in this part, and the second time was at the end of the second part when they were flying away in Kim's car. (edit) The running gag where someone interrupts Kim and Ron kissing is finally broken in this episode. They did kiss in the episode Oh No! Yono!, but it was brief due to Hana jumping between them. (edit) In this episode, we finally find out what Mrs. Dr. Possible's name is. Her husband's brother, Slim, calls her by the name "Annie". This also explains where Kim got her middle name. (edit)

The Second Coming:

Barkin: The centre cannot hold.

This line by Barkin is a direct quote from the W.B. Yeats' poem "The Second Coming." (edit) People:

The magazine featured in this episode is called Humans, which is a reference to the very popular real-life magazine People. (edit) Spaceballs:

Barkin: Soon the now will be the past, and the future, the new now.

This is a reference to Spaceballs, with the "When will it be then?" gag when they search for themselves in Spaceballs: The Movie. (edit) Resident Evil 2:

Drakken's mutation is a direct pass at the Resident Evil 2 game, with William Birkin's mutation into the Tyrant when dropping the G-virus sample. (edit) Gilligan's Island:

When Kim and Ron are making their move on Duff Killigan's headquarters, over the communicator, Wade calls it Killigan's Island. This is a play on the name of the very popular TV series Gilligan's Island. (edit)