Grey's Anatomy

Deterioration of the Fight or Flight Response

Season 2, Ep 26, Aired 5/15/06
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  • Episode Description
  • Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke. Part 2 of a three-hour season finale. This episode is the first hour of a two-hour episode which is two hours long and will air on a Monday in a different time slot than it would on Sunday. Aired on Monday, May 15, 2006 from 9 PM EST to 10 PM EST.moreless

  • Cast & Crew
  • Ellen Pompeo

    Dr. Meredith Grey

  • Sandra Oh

    Dr. Cristina Yang

  • Katherine Heigl

    Dr. Isobel "Izzie" Stevens

  • Justin Chambers

    Dr. Alex Karev

  • T.R. Knight

    Dr. George O'Malley

  • Fan Reviews (34)
  • Burke's hand and Denny's life are at risk.

    By attilasd, Jul 05, 2006

  • Burke is injured and Christina can\'t handle it. Denny\'s life hangs by a thread along with Izzie\'s career. Callie anxiously waits for George to return her love. The entire staff attends a prom for the chief\'s niece. Mer and Der hook up once more.

    By Burktina, Jul 04, 2006

  • "Grey's" continues it's tailspin, out of control and headed straight for a mountain... no, a volcano... an ERUPTING VOLCANO of tastless cheese... please put your tray tables in their upright and locked position and keep your barf bag close by!

    By Frennis, May 22, 2006

  • Amazing!!!

    By Millie10, May 16, 2006

  • DENNY DIES!!!!!!!!!!!!!!!!!!!!!!!!!!!! OH MY GOD!!!!!!!!!!!! in 2 second part of finale it air as 1

    By Halo23OTH, May 16, 2006

  • Trivia & Quotes
  • Quotes (23)

    • Richard: Derek, is the arm paralyzed? Derek: We have to do a wake up test. Richard: Derek. Derek: There's only one person who can help me figure out if I've damaged the relay or not and that's Burke. Richard: He's been through a lot of trauma today. Derek: I'm trying to prevent the trauma he's going to feel if I have to tell him he's paralyzed.

    • Burke (about to have surgery): Shepherd. Derek: You don’t have to thank me. I’m sure you’ll return the favor one day. Burke: I was going to say please try not to kill me. (they all chuckle) Derek: I'll do my best.

    • Derek: You could take up fishing. Burke: I don't fish. Derek: Fishing is a lot more fun than surgery. Burke: I have 80 percent hand function now. Derek: Mmm. 80 percent is not enough. Not for you. Burke: Fishing, huh? Derek (smiles): You don't fish.

    • Richard: There's never a good place to hide in this hospital. Derek: I'm trying to get perspective. It feels enormous, like it's all- I- I- I can't get perspective. Richard: My niece's cancer has come back. She's 17 years old and she's gonna die. (pauses) ... Plus ... 25 years ago I had a secret affair with ... Ellis Grey. (Derek looks up at him at this) And today I find out that my wife knew the entire time. (Derek sighs and sits back into the couch) There was no secret. And she stayed with me. Derek: I respect him, you know? Dr. Burke, I- I respect him. He's decent. He's honorable. An arrogant ass who just hogs the O.R and thinks he's God but … he's decent and he's honorable. I respect him. He's one of the foremost cardiothoracic surgeons in the country and I've gotta just ... It's his hand. I can not get perspective. I can't do this. I can't be responsible for him. Richard: Preston is an honorable and decent man but Derek, so are you. (Derek just shakes his head) You are honorable and decent and you're too honorable and decent to run. (Derek just remains silent and Richard looks at the coffee cup in his hands) You don't know how much I wish this was bourbon.

    • Alex (on the phone): He's been shot! Dude! Meredith: We're going to have to run the test ourselves. Alex: UNOS gave us an hour. In a couple of minutes our time is up. I'm telling you this chick is hardcore. She's not going to wait. Meredith: Okay, okay, you just have to stall her. Alex: I'm not getting involved with this! Look I don't care if that- that drawling bed whiner ever gets a heart. Meredith: Alex. Do this. For Izzie. Alex (looks comtemplative): I'm not guaranteeing anything!

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    Notes (3)

    • The starting narration of this episode saw every main character appearing in the episode contribute snippets of speech.

    • Original International Air Dates: Bulgaria: August 1, 2006 on bTV Venezuela: August 25, 2006 on Warner Channel Spain: October 2, 2006 on Cuatro Australia: October 23, 2006 on Channel Seven Netherlands: December 5, 2006 on Net 5 UK: January 25, 2007 on Living TV. Norway: February 06, 2007 on TV2 Croatia: April 30, 2007 on NOVA TV Finland: May 2, 2007 on Nelonen Italy: May 11, 2007 on Italia 1 Ireland: July 17, 2007 on RTE2

    • Music Featured In This Episode: 1. Universe And U by KT Tunstall plays when Derek tries to hide in a room but ends up exchanging worries with Richard. 2. Look At Her Face by The Coral Sea plays when Dr. Hahn and Alex arrive at Seattle Grace by helicopter. 3. Through The Backyards by Au Revoir Simone plays when Dr. Hahn performs Denny's heart transplant. 4. How We Operate by Gomez plays when Derek must perform a wake-up test during surgery to check Burke's hand for nerve damage.

    Allusions (2)

    • Bailey: Do not pass go. "Pass go" is making reference to the board game Monopoly. Players start on the square "Go" and receive $200 every time they pass it. The aim of the game is to buy property, build on them and monopolise the entire board. A player wins once everyone else is bankrupt. When you get sent to jail through Chance or Community Chest the card says "Do not pass go."

    • Episode Title: Deterioration of the Fight or Flight Response This episode's title could be a reference to the 2002 The Flaming Lips song of the same title. Also, the Fight or Flight response is a medicial term first described by Walter Cannon in 1915. His theory states that animals react to threats with a general discharge of the sympathetic nervous system, priming the animal for fighting or fleeing.

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