A man who assures to be a wolf man takes Jack and his personnel as hostages in Jack's apartment, where they had met to try to solve the budgetary crisis of the hospital.
Arturo and Chloe ask Jack for help to treat Brian, a patient who "by accident" has cut two of his fingers and refuses to allow a surgeon to re-implant them.
When Clay, a veteran of the Iraq War, shots himself in the hand in front of his family, Jack treats him by trying to help him remember the assault that traumatized him during the war, this gives surprising results.
Billy a construction worker who suffers the physical and psychological pain of an accident at work, starts showing symptoms of an accident almost identical, but more serious that took place over a hundred years ago. Jack and Carl find it difficult to diagnose and treat him. Meanwhile Veronica and Rylan's relationship is put in jeopardy and Jack continues to search for his missing sister.
Jack tries to help an autistic traumatized girl discovering the person who murdered her father, since she is the only witness. Meanwhile, Arturo receives the inconvenient visit of his own father, an actor of a soap opera who interprets a doctor in television and thinks he can help his son solve a medical case.
A 16 year old girl attempts to commit suicide by lighting herself on fire. Jack and his team discover a big secret about her real identity. Meanwhile, Dr. Zan and Jack keep getting closer.
A man obsessed with cleanliness, which suffers from an obsessive compulsive disorder and Tourette's Syndrome, reaches the hospital to surrender to an operation that has never been tried before with the hope that it cures him. Meanwhile, the hospital personnel discovers that is his wife the one that pressures him to get surgery, in spite of the fact that she also has to fight against a serious disease.
Jack is very busy trying to prevent a gambling addict from committing suicide, and in addition to that he has to testify in a trial for murder, as an expert, to prevent that an innocent and mentally incompetent man gets imprisoned unfairly.
A famous actor is admitted to the hospital after having suffered what looks like a psychotic outbreak during his appearance in a Live Talk Show. He confesses that he has faked it to prepare for a movie role, but Jack suspects that he suffers from a serious personality disorder.
An 8 year old boy suffering from bipolar disorder is secluded to the hospital after an incident with a knife. Jack finds out the only way to help him is by playing a video game existing only in the boy's head. Meanwhile, Nora is having problems with her daughter and Jack continues looking for his missing mentally ill sister.
Jack attempts to give a highly unorthodox treatment to a famous philosopher who is in a catatonic state due to a lightning strike that crippled him and killed his wife. Meanwhile Jack gets in a complicated situation as he feels attracted to a patients daughter.
Jack and Veronica are called to treat a woman who believes she is pregnant, but the ultrasound reveals there is no baby. Meanwhile, Jack searches for his mentally ill sister, who he thinks is homeless and may be wandering the streets of Los Angeles.
Dr. Jack Gallagher spends his first day as Director of Psychiatric Services at Los Angeles' Wharton Memorial Hospital trying to win over his colleagues and his boss Nora Skoff.
