The struggle for land between American Indians and the white settlers explodes when the ruthless Hessian Colonel Von Weber declares that all Native Americans must be slaughtered. The commander attacks Chief Pontiac's people, burning their villages, murdering women and children. Pontiac retaliates by kidnapping white women as his tribe prepares for war. A lieutenant sympathetic to the Indians convinces them to release the captives and negotiate a truce with the Redcoats. Hopes for peace are dashed when Von Weber enacts a grisly plan to infect the natives with smallpox. With their people in agony and their homelands doomed, nothing can stop the furious revenge of Chief Pontiac and his braves, who prepare a horrific fate for the bloodthirsty colonel.