Beethoven's 2nd is the movie return of the Newton family, and their famous dog, the St. Bernard named Beethoven. This time Beethoven is back with his female match, Missy. Missy's owners are settling a divorce, and planning to move her away. Beethoven helps her escape and they fall in love, and Missy has 4 puppies, Tchaikovsky, Chubby, Dolly and Mo. When Missy's owner Regina discovers the puppies, she takes Missy and plans to get rid of the puppies, even if it means killing them. The Newton kids Ted and Emily carry them home and hide them from their parents, taking on the responsibility of taking care of the puppies, while Regina plans revenge. Can the kids hide the puppies from their parents and keep them out of the clutches of the evil Regina? Join Beethoven, Missy, the new puppies and the Newton family for more canine fun and adventure in Beethoven's 2nd.