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Eduardo Mignogna's comedy drama Cleopatra tells the tale of friendship between two women who need to reevaluate their lives. Cleo (Norma Aleandro) is having a mid-life crisis. Her nearly four-decades-old marriage is wilting as her husband is becoming an alcoholic after being out of work for two years. Her grown sons have little meaningful contact with her. She works as a teacher, but must sell makeup door-to-door in order to survive. Remembering her dreams of becoming an actress, she auditions for a new television show. While at the audition, she meets Sandra (Natalia Oreiro), a soap opera actress who is chaffing under the control of her manager/husband. The pair escape together and go on a road trip in which Sandra falls in love and reconciles with her family, while Cleo grows to accept where she is in life.