Flash Gordon: The Purple Death from Outer Space sees Flash, (Buster Crabbe) once again at the mercy of Ming the Merciless, (Charles Middleton) ruler of planet Mongo. A strange and lethal disease has infected planet Earth leaving its victims with an odd purple spot on their foreheads. On a mission to stop this plague and with Earth's future resting their shoulders, Flash Gordon, Dr. Zarkov (Frank Shannon) and Dale Arden (Carol Hughes) venture into space to locate the source and to find an antidote to the deadly disease. Discovering it's the dirty work of Ming the Merciless, they find themselves involved in a captivating aerial dual, an intensive battle with enormous mechanical men on the frozen plains of the planet Frigia, all to find the antidote and bring an end to the devious plans that Ming's warped mind has for planet Earth. This is an epic adventure but can Flash and his friends save planet Earth?.