Frankenstein Must Be Destroyed is the fifth Hammer Production horror movie centering on the Frankenstein character. Baron Von Frankenstein (Peter Cushing) is an unethical doctor performing illegal experiments. His close friend and colleague Dr. Brandt (George Pravda) is slowly dying from oxygen deprivation of the brain and needs an extreme operation to save his life. After Baron Frankenstein discovers that the fiance (Simon Ward) of Dr. Brandt's landlady, Anna (Veronica Carlson), is stealing medicine to help her sick mother, he blackmails them into helping him with his experiment. Baron Frankenstein transplants Dr. Brandt's brain into a stolen corpse. Although the operation is a success, once the doctor awakens and sees his monstrous appearance, he runs away. Dr. Brandt seeks refuge with his wife Ella (Maxine Audley), but she no longer recognizes him and rebuffs his advances. Outraged by the experiment and his appearance, Dr. Brandt is determine to wreak havoc against the individuals who made him into a monster.