From Hell, the 2001 thriller based on Alan Moore's graphic novel, stars Johnny Depp as a detective searching for the elusive Jack the Ripper in Victorian London. Inspector Frederick Abberline (Johnny Depp) is assigned to investigate the gruesome murders that have shaken all of London and especially the lower-class district of Whitechapel, where the Ripper stalks impoverished prostitutes. Abberline's professional involvement with the case becomes personal as he falls in love with Mary Kelly (Heather Graham), one of the group of prostitutes targeted by the serial killer. When Abberline tries to piece together why the Ripper wants to silence the women, he is drawn into a dangerous underworld of Masonic secrets, supernatural rituals, and a conspiracy that may reach as high as the Royal Family. As the murders continue, putting Mary Kelly in ever greater jeopardy, Abberline's addiction to opium threatens to derail him before he can discover Jack the Ripper's true identity.