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When Sheriff Berger (Robert Englund) executes serial killer Chambers (James Binkley) in the electric chair, it seems it?s the end for the world?s most violent criminal ? but it?s only the beginning. Chambers escapes from the hospital morgue and proceeds on a bloodthirsty rampage through the locked down hospital. Fighting alongside Sheriff Berger are young hospital patients Sara Wexler (Meredith Henderson), and Walter (Nathan Stephenson). The two youths struggle to stay alive in a hospital rapidly filling with blood, with the help of Nurse Grafton (Laura De Carteret). Chambers? thirst for violence grows with every gruesome murder and it becomes clear that although he relies on the souls of others to survive, he is particularly fixated on that of Sara Wexler with whom he shares an unholy bond. In a brutal showdown Chambers kills Sheriff Berger, leaving Sara and Walter to fend for themselves against the supernatural evil. Trapped in the hospital, they can only run for so long.