Management candidate Nick Hendricks (Jason Bateman) has been logging 12-hour days and eating everything his twisted supervisor Dave Harken (Kevin Spacey) dishes out, only to find he's never getting promoted. Meanwhile, dental assistant Dale Arbus (Charlie Day) has been struggling to maintain his self-respect against the relentless X-rated advances of Dr. Julia Harris, D.D.S. (Jennifer Aniston). And accountant Kurt Buckman (Jason Sudeikis) has just learned that his company's corrupt new owner, Bobby Pellit (Colin Farrell), is not only bent on ruining his career but plans to funnel toxic waste into an unsuspecting population. So, on the strength of a few-too-many drinks and some dubious advice from a hustling ex-con (Jamie Foxx), the guys devise a convoluted but foolproof plan to rid the world of their respective employers... permanently. But even the best-laid plans are only as good as the brains behind them.