This colorful, modern comedy revolves around 10-year-old boy genius Henry James Herman (Jason Spevack) and his fervently left-wing single mother Patricia (Toni Collette), who works at the local university's cafeteria. A misfit from birth, Henry's precocious, rabble-rousing ways catch up with him when he gets kicked out of school for writing "Manifestos on the Nature of Truth." Meanwhile, 12-year-old Audrey (Samantha Weinstein) has her own problems because of her single father, university professor Dr. Slavkin O'Hara (Michael Sheen), who used her as the test subject for his best-selling book Born Gay or Made that Way? Needless to say, she gets a not-so-nice nickname from her classmates. When Henry scores a scholarship to the university as a child prodigy, the two families cross paths and everything they knew about their lives is thrown to the wind.