Land Raiders follows the story of the brutal landowner, Vince Carden (Telly Savalas), who will do anything to drive the Indians from his land. His empire grows as he takes away the property of the natives, paying locals for the scalps of Indians. His ruthlessness has alienated him from his brother, Paul (George Maharis). His wife, Martha (Arlene Dahl), is disgusted with him and consequently is emotionally withdrawn, but nothing will stop Vince's greed. Meanwhile Paul is traveling on a wagon train that is attacked by Apaches bent on revenge for Vince's brutality. He is one of the few survivors of the attack, along with Kate (Janet Landgard), who stays by his side. This only fuels Vince's rage all the more, and he sets out to retaliate himself. The bloodthirsty feud between Vince and the natives will ultimately lead to a confrontation between the two brothers, a stand-off that will decide the fate of the family and Vince's dominion.