Life of Sin is a dramatic film encapsulating the life and career of Isabel La Negra (Miriam Colon), a Puerto Rican woman who came from poverty to become a famous and wealthy proprietor of a brothel. Paulo (Raul Julia), a reporter from South America, is fascinated with the story of Isabel La Negra, how an impoverished young girl from Puerto Rico can become the owner of a famous brothel, catering to the most illustrious and successful men around. As he delves into the life of the owner of the one of the most famed brothels in Ponce, her life story come to life around him, with all the richness of a true rags to riches narrative. From her poor, humble, beginnings to her unfortunate, controversial death, La Negra's remarkable determination and relentless pursuit of success is highlighted. This introspective biopic, directed by Efra'n L'pez Neris thoroughly scours the life of the famed madame, one of the most enigmatic figures ever.