Man with the Screaming Brain is a 2005 science-fiction action comedy directed by Bruce Campbell. In the film, William Cole (Bruce Campbell) is a rich businessman who has been murdered by a mysterious woman killer. Yegor (Vladimir Kolev) is a Bulgarian street hustler who also has been killed by the same woman. Fortunately for the two murder victims, a mad scientist, Dr. Ivanov (Stacy Keach), has managed to save them by performing an experimental surgery on them. The crazy doctor swapped part of Cole's brain with a piece of Yegor's, and now both men are surviving in the same body. Although the two men are unlikely partners, they find themselves working towards the same goal. Both men want to catch the woman responsible for their deaths. Will the men be able to catch their nemesis, or will they be forced to share the same body for the rest of their existence?