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Meteor Apocalypse is a science fiction thriller, following the struggles of a man to reunite his family in the aftermath of a catastrophic meteor strike. When a massive meteor is detected on a collision course with Earth, the world's leading countries band together to prevent the destruction of the planet. They fire a barrage of nuclear weapons at the meteor, successfully destroying it, but leaving radioactive debris in its wake. David Dematti (Joe Lando) is at home with his wife, Kate (Claudia Christian), and daughter Alison (Madison McLaughlin). He gets called into his workplace, a water treatment facility, where he learns the radioactive debris from the meteor is raining down on the Earth, poisoning the water with a fatal infectious disease. The government institutes a quarantine on those who drank the water, including Kate and Alison. It is up to David to find a cure and rescue his family before the disease runs its course.