Quid Pro Quo follows the life of Isaac Knot (Nick Stahl), a reporter whose life was changed during a serious car accident which took the lives of his parents and rendered him paraplegic. As a radio talk show host, he has the opportunity to come into contact with a wide variety of individuals from all walks of life. However, his curiosity is sparked when he discovers a small subculture of people who actually yearn to be handicapped. Some even go as far as to have normal, working limbs amputated to achieve their dream of being handicapped. At first, Isaac can't seem to discern why anybody would wish this upon themselves. To gain answers, he takes to the streets in an attempt to locate this group and catches a small glimpse into their minds. In doing so, he meets Fiona (Vera Farmiga), and the two grow very close emotionally and physically.