Road of No Return is an action-packed and adrenaline-fueled movie, where four hit-men are put together in a covert group to take out a very high-profile drug traffickers. They are each in search of their own redemption as lost souls traveling the earth. But during their mission their goals change after they save the life of a downtrodden orphan girl. From then on the scales swing against them when their roles are reversed and the hunters become the hunted; their employers begin an effort to cut their loses. The company will tirelessly hunt them down for they will not accept delays. J.Marcone (Michael Madsen) and Mr.Hover (David Carradine) head this group of four hitmen in their assignment to take down the drug traffickers as it turns into a fight for their own lives. The hit-men each will find their own salvation through the help of the girl and realize their troubles within.