The Big Empty is a science fiction thriller. John Person (Jon Favreau) is an out of work actor in Los Angeles, with close to $30,000 in debt. With no job in sight, things seem hopeless. However, John's oddball neighbor, Neely (Bud Cort), barges into his apartment and offers him a job. John will receive $25,000 to deliver a large blue suitcase to Cowboy (Sean Bean) at a truck stop in Baker. John doubts Neely's proposition, but Neely pulls out an in-depth dossier on John. John negotiates to do the job as long as it covers his exact debt. Once he goes to the desert, he encounters strange people. He checks into the Royal Hawaiian Motel, managed by Elron (Jon Gries), who is annoyingly optimistic. The easiest job in the world, soon turns to be much more. Will John drop off the suitcase and pay off his debt? Or will he run into more trouble?