The Man Without a Body takes science fiction to the limit in 1957 as a wealthy industrialist, Brussard (George Coulouris), seeks to beat death with the help of a mad scientist. Dr. Phil R. Merritt (Robert Hutton) experiments with mixing and matching monkey heads with new monkey bodies and Brussard hopes Merritt can find a new head for his body, which is dying with a brain tumor. The two steal the severed head of 16th Century physician, mathematician, astronomer, and prophet Nostradamus to use for the operation. Merritt believes the transplanted brain will take on characteristics of the body's former brain, including life experience, intellect, personality and ego, to effectively extend the life of the dying man, but the brain would keep its knowledge and characteristics, as well. What ensues is a battle of wills between the two and Nostradamus uses his gifts of foresight to teach the millionaire a lesson.