Timbuktu is a rollicking story featuring political upheaval and a steamy love triangle. It takes place in 1940, set in a French garrison in Timbuktu. A new Commander, Colonel Dufort (George Dolonez), and his attractive wife, Natalie Dufort (Yvonne De Carlo) have arrived to take over the garrison. They are greeted with a Tuareg rebellion, led by a supposed friend of France and holy man, Mohamet Adjani (Leonard Mudie). The rebellion is also partly supported by American soldier Mike Conway (Victor Mature), who supplies arms to the Tuareg soldiers. Seeking to protect his wife, Dufort enlists Conway to escort the two of them to a safer city nearby, Bou Djebeha. On the way, Natalie Dufort and Conway embark on an illicit romance. Once they arrive, Dufort realizes that Adjani has been kidnapped and that there are more sinister forces behind the rebellion, and is forced to ask his wife's lover for aid in ending the rebellion.