Time to Leave is a drama that follows a homosexual photographer, Romain (Melvil Poupaud), who is diagnosed with terminal cancer. He seeks the solace and companionship of his grandmother, Laura (Jeanne Moreau), during this time and does not disclose his diagnosis with the rest of his family. He even withdraws from his lover, becoming very apathetic and distant in the wake of his illness. After spending a decent amount of time revisiting his childhood with his grandmother, he attempts to return to his former life only to find everyone cross with him. It is not until he meets an unlikely acquaintance that he begins to find meaning in life. He meets a waitress, Jany (Valeria Bruni Tedeschi), who strikes an odd deal with him and gives him a unique proposition. It will take all the emotional strength he can muster to come to terms with the recent events in his life, and he is short of time.