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When Rin is taken hostage by the enemy ninja, Obito becomes determined to save her. Not willing to end up like his father, Kakashi would rather carry out the mission than save Rin. Can Kakashi and Obito work out an agreement? Will Rin be saved? Witness the shocking origin of Kakashi's Sharingan!
Before the start of the series, during the Third Great Shinobi World War, a young ninja named Kakashi Hatake has just recently been promoted to the rank of Jonin. Together with his teammates, Obito Uchiha and Rin, and his mentor, the future Fourth Hokage, they set off on a mission to destroy a bridge and prevent the Stone ninja from getting supplies.
After successfully convincing Jugo to join his team, Sasuke finally has everyone he needs for his platoon. He names his platoon Team Hebi, and explains the true reason as to why he gathered them all together. Back in Konoha, Naruto takes a guess on what Sasuke is planning and proposes a new plan to everyone: they must find and capture Itachi Uchiha.
Having successfully recruited Karin, Sasuke seeks out the final member for his platoon, Jugo. Karin warns Sasuke and Suigetsu of Jugo's uncontrollable murderous instincts, but as they arrive at the northern hideout, they find another matter they must attend to first. Elsewhere, shocking news reaches the ninja of Konoha.
Sasuke and Suigetsu seek out the next member Sasuke hopes to recruit for his team, Karin, a woman who controls one of Orochimaru's prisons. As Sasuke tries to convince Karin to join his team, Suigetsu releases Orochimaru's prisoners under Sasuke's order, but only on one condition.
Having defeated Orochimaru, Sasuke releases one of Orochimaru's test subjects, Suigetsu. Determined to put together a team to achieve his goals, he decides to request Suigetsu's assistance. Suigetsu agrees, but only if he's willing make a detour to the Land of Waves first.
Orochimaru reveals the true, hideous form his body has taken from years of experimenting on his body. Can Sasuke defeat this menacing form, or does Orochimaru still have a few tricks up his sleeves?
Orochimaru's body has reached its limit and the time for the ritual has come. Sasuke has other plans, however, and seeks to target a bedridden Orochimaru.
The battle for the Sanbi comes to an end as neither the Konoha ninja nor Orochimaru are successful at obtaining it. Tsunade classifies the mission of catching the Sanbi as a failure, for it is too dangerous to accomplish. As Naruto and the others prepare to return home, Yukimaru goes missing. Unbeknownst to everyone, Akatsuki lies in wait, and they have their own plans for the Sanbi.
The sealing team continue their efforts to seal the Sanbi while Kakashi and the others face against a monster created by the fusion of Kigiri, Nurari and Kihou. Kabuto reveals Orochimaru's plans involving the Sanbi and he and Naruto begin to fight. While protecting Yukimaru, Guren fights against the real Rinji, who has been resurrected by Kabuto. When Guren sacrifices her life to save Yukimaru, Yukimaru's powers go into full effect. Now, in order to protect Yukimaru, Naruto prepares to go against the rampaging Sanbi.
Katsuyu arrives to help the sealing team with the sealing barrier. Naruto and Guren arrive to save Yukimaru from Rinji, but after Guren and Yukimaru have a brief discussion, Rinji reveals the truth about Guren to Yukimaru in hope that he'll make the Sanbi go wild. What will Yukimaru's reaction be when he discovers Guren killed his mother?
The sealing team once again attempts to use the Four-Corner Sealing Barrier on the Sanbi after Naruto and Guren are set free, whom are nowhere to be seen. Sai is ambushed, while Yukimaru is kidnapped by Kihou, Kigiri and Nurari after Kakashi orders Sai to take Yukimaru to safety. The trio give Yukimaru to Rinji, who reveals to them the cost of the Cursed Seal. After that, the trio attempt to destroy the barrier but are stopped by Yamato, Shino, and Kakashi. Elsewhere, Rinji forces Yukimaru to use his powers. Where are Naruto and Guren with all the events taking place?
Yukimaru informs Kakashi and the others to Naruto and Guren's whereabouts and they attempt to free them with Yukimaru's help. Kiba, Tenten and Lee once again battle Kihou, Kigiri and Nurari after gaining more power from Kabuto. Naruto and Guren continue to search for a way out, coming across human-sized Sanbi-like creatures and illusions. Will Naruto and Guren ever find a way out?
Sai, Hinata, Kiba, Yamato, Shizune, and Kakashi search for Naruto while Sakura and Ino are healing Yukimaru. Naruto and Guren find themselves swallowed by the Sanbi and are attacked by miniature Sanbi-like creatures. Naruto and Guren decide that they must work together if they are to escape from the Sanbi. Meanwhile, Kabuto decides to help Kihou, Kigiri and Nurari.
Yukimaru stops the Sanbi from killing Guren, but the Sanbi then attempts to attack both of them. Rinji stabs Guren in order to trigger Yukimaru's Sanbi-controlling powers, but his chakra reaches its limit. Naruto notices Yukimaru using his powers and runs off to search for him, and soon finds himself fighting the Sanbi alongside Guren.
The Sanbi gets trapped in the sealing barrier and Kabuto plans to destroy the barrier. While Guren fights Lee, Tenten, Naruto, and Shino and Rinji once again attempts to destroy the barrier, the Sanbi brakes loose.
After Shino finishes gathering chakra for his insects, he goes against Guren's Crystal Style. Elsewhere, while Shizune, Sakura, Ino, and Hinata are bringing the sealing barrier to the Sanbi, they are being watched by Tobi and Rinji. Rinji decides to make a move.
The sealing unit prepares the sealing barrier and the other two teams go into battle with Guren and her henchmen. Naruto, Kakashi, and Sai stall Guren and Gozu while Shino prepares to go against Guren's Crystal Style. Meanwhile, Lee goes up against Guren's other henchmen and gets trapped in their smokescreen. Can Lee find a way to defeat them?