Cast updates: Grey's, pilots

Three actors with considerable experience on both the small screen and the big screen have signed on for new roles, reports Variety.

Seattle Grace's revolving door of doctors is turning once again, this time welcoming a familiar face to fans of late-1990s-early-2000s soapy teen dramas. Joshua Jackson, who played Pacey Witter on the popular Dawson's Creek, will be doing checkups as a guest star on Grey's Anatomy.

Jackson will play a doctor in multiple episodes beginning in this season's 11th episode. Since Dawson's ended, Jackson has largely worked in smaller, independent films. The 29-year-old is also rumored to play the lead in the upcoming Fletch prequel.

Carrie-Anne Moss, who had her breakout role as Trinity in the Matrix trilogy, will star in the upcoming FX pilot Pretty Handsome (formerly 4 oz.) from Nip/Tuck creator Ryan Murphy. In typical bizarre Murphy fashion, the show centers on a transsexual (Joseph Fiennes) who undergoes a sex-change operation. Moss will play Fienne's wife.

Larenz Tate, who lit up the big screen as the insane O-Dog in 1993's Menace II Society and recently played Quincy Jones in Ray, will play a cop in the NBC drama Blue Blood. Tate is hoping to break his recent string of acting in failed shows. The actor was among the cast of two 2006 duds on CBS, Waterfront with Joey Pantoliano (which never made it to air) and the short-lived Love Monkey.

Elsewhere, Megan Dodds and Christina Vidal have joined an untitled NBC drama pilot to be directed by Barry Sonnenfeld, according to The Hollywood Reporter. The show, which stars Firefly's Alan Tudyk, follows some very driven New York City lawyers doing the whole corporate ladder thing. In other Sonnenfeld news, the director-slash-producer has been assigned to both roles of the tentatively titled 1980's cop comedy Buddies.

Sonnenfeld, director of several films including Men in Black and its sequel, has been spending more time on television. His recent projects include Notes from the Underbelly and Pushing Daisies.