Grey's Anatomy casting shakeup continues

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There's a lot going on in the world of Grey's Anatomy, but who cares about that fake-doctor drama when you can focus more on the real-actor hissy fits going on when the camera isn't rolling? The latest from Seattle Grace says two regulars are definitely on the outs at their request.

Katherine Heigl and T.R. Knight will both be leaving the show, actor James Pickens Jr. (Dr. Richard Webber on Grey's) told US Weekly.

"Wherever Katherine goes, I wish her nothing but the best," Pickens said after confirming her departure. When asked about Knight, Pickens said, "He's going too. He just wanted to pursue other career paths."

However, this doesn't mean they're out the door just yet. As EW.com points out, they still have a little thing called a "contract" to sort out. The site also says that their futures are really in the hands of their agent's and ABC's lawyers, and a source says "it's a safe bet that Katherine and T.R. won't be returning as series regulars next season."

Both actors have allegedly expressed interest in leaving Grey's Anatomy; Heigl to pursue a film career and Knight to go somewhere he can get more air time.

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