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Lisa, famous for playing kooky Pheobe in Friends, is the first star to trace her family tree and in a trailer for the programme she is shown welling up, before making a nervous phone call saying: "Hello, my name is Lisa Kudrow... and I think we're related."
The actress told Entertainment Tonight: "Scavenger hunt, that's a good way to put it, that's what it feels like."
Brooke's investigations with the show's team of experts lead her to discover she may have descended from royalty.
Lisa revealed: "She has her mother's side from New Jersey and her father's side which she said are like New York society, Italian aristocracy, and she wasn't ever sure where she fit in."
Who Do You Think You Are? begins with Lisa's story at 8pm on NBC on Friday night.