Phina will play Gabby, mother to son Taylor and daughter Amber, when the family hits screens this summer.
Producer Paul Marquess told the soap's official website: "We will meet Gabby Sharpe - and her teenage children Taylor and Amber - in dramatic circumstances. Their arrival in Hollyoaks will change the life of a much loved character forever."
Actress Phina is best known for playing Footballers' Wives Liberty Baker.
Sixteen characters are being written out of the teen soap this year as the new producer overhauls the show.