Famke Janssen makes her triumphant return to Nip/Tuck tonight as life coach/life ruiner Ava Moore. To celebrate, we've rounded up the 10 Nip/Tuck guest stars who've performed the show's most successful augmentations.
First Appearance: “Erica Noughton”
Most Recent Appearance: “Alexis Stone II”
Veteran actress Vanessa Redgrave got to play mom to her real-life daughter Joely Richardson when she booked her guest stint on Nip/Tuck. Erica’s unapologetic villainy eventually transitioned to something slightly more sympathetic. She’s still the mother from hell, but you have to feel a little sorry for her.
Rosie O’Donnell (Dawn Budge)
First Appearance: “Dawn Budge”
Most Recent Appearance: “Rachel Ben Natan”
Like her character, Rosie O’Donnell is outspoken, tactless, and divisive. True, Dawn Budge was one of the most irritating characters ever to grace Nip/Tuck, but she was also one of the most interesting. If this were Lost, we could postulate on her cosmic bad luck, but as it stands, we’ll just say she’s a magnet for injury—with hilarious consequences!
Seth Gabel (Adrian Moore)
First Appearance: “Bobbi Broderick”
Most Recent Appearance: “Joan Rivers”
Janssen got a lot of attention for playing the corrosive Ava, but where would she be without her son-lover Adrian? Before living it up as Jeremy Darling on Dirty Sexy Money, Seth Gabel was perfect as Ava’s twisted progeny. Things were bad enough when he started palling around with Matt, but remember the shock when he first locked lips with mom?
Sharon Gless (Colleen Rose)
First Appearance: “Magda and Jeff”
Most Recent Appearance: “Ronnie Chase”
The very talented Sharon Gless had a real challenge in Colleen Rose. First she was sad, then she was creepy, then she was turning rival talent agents into life-size teddy bears. Gless was adept at making the audience feel for Colleen—until she stabbed the hell out of Sean, at which point it was time for her to go.
First Appearance: “Monica Wilder”
Most Recent Appearance: “Conor McNamara, 2026”
There just aren’t enough quality roles for little person actors; maybe that explains why Peter Dinklage is in both the original Death at a Funeral and its American remake. But I digress. As Marlowe, Dinklage was a supportive and sensual partner for Julia, the perfect alternative to Sean’s creepy nanny. Infidelity with a heart.
First Appearance: “Joan Rivers"
Most Recent Appearance: “Christian Troy II”
You think maybe Joan Rivers has had some work done? Hey, she’s the first to admit it, and her work on Nip/Tuck shows that the classic comedienne has a great sense of humor. In one of the show’s funniest moments, she sees what she’d look like without plastic surgery (not great). In another, she goes gaga over face cream made from—well, this is a family site.
Mario Lopez (Dr. Mike Hamoui)
First Appearance: “Monica Wilder”
Most Recent Appearance: “Joel Seabrook”
Slater! Just kidding—he hates that. This is the new, more mature Mario Lopez, and he certainly bared his backside enough to remind us of that. Let’s be honest, Mike was never the most integral character; he really stuck around just to make Christian feel inadequate. But Lopez managed to make him at least somewhat likable.
Bradley Cooper (Aidan Stone)
First Appearance: “Carly Summers”
Most Recent Appearance: “Manny Skerritt”
Part of the new cast ushered in after McNamara-Troy moved to Beverly Hills, Bradley Cooper’s Aidan was the ultimate Hollywood tool. He also provided great moments of comic relief in a season that, frankly, wasn’t the show’s best. It’s a shame he hasn’t signed on to return before the series’ end.
First Appearance: “Blu Mondae”
Most Recent Appearance: “Willy Ward”
If you don’t believe that Nip/Tuck has amazing star-drawing power, just look at Jacqueline Bisset. Not only did they get her for seven episodes—they had her playing the leader of an organ-stealing ring. Like so many of the women on this list, Bisset was one of the bad guys, but she did evil with elegance.
AnnaLynne McCord (Eden Lord)
First Appearance: “Everett Poe”
Most Recent Appearance: “Giselle Blaylock & Legend Chandler”
On 90210, AnnaLynne McCord plays a mean girl with a heart of gold. On Nip/Tuck, she played a mean girl with the capacity to slowly poison her mom’s girlfriend before shooting her in the head. They never really resolved her storyline, though Eden did get a great closing scene, throwing her dead mom’s ashes on a stunned Sean and Julia.
Who's been your favorite Nip/Tuck guest star?
Follow TV.com writer Louis Peitzman on Twitter: @LouisAtTVDotCom