Ross has created a vampire storyline for the adult mag CLiNT which is due to be published from September.
It is being launched by comic writer Mark Millar, whose Kick-Ass has been developed into a hit movie, scripted by Ross's wife Jane Goldman.
Millar will unveil his follow-up story when it is serialised in the new magazine, published by Titan Books.
Kick-Ass 2: Balls To The Wall is also set to be turned into a movie and is due for 2012 cinema release.
Ross - who is due to leave his BBC1 and Radio 2 shows in the summer when his contract ends - has long been a comic fan and has made TV documentaries about his passion. He also created his own graphic novel Turf with artist Tommy Lee Edwards.
CLiNT will include a serialisation of Turf plus other stories.
Ross and Boyle - who recently left the line-up of panel show Mock The Week - are the first of a range of high-profile figures lined up for the future.
Millar said: "This is The Eagle for the 21st Century."
His new magazine will also include features and interviews as well as four comic strip serials each month.