It's the weekend -- Jesse Metcalfe is back on Desperate Housewives!
Here's what we'll be watching ...
FRIDAY, OCTOBER 9
8 p.m., FOX
Brothers
Snoop Dogg guest-stars as Mike (Michael Strahan) and Chill's (Daryl "Chill" Mitchell) lawyer cousin. What a complex image.9 p.m., CBS
Medium
Tate Donovan is in the director's chair for this episode, as Allison (Patricia Arquette) suspects a hospital employee might be responsible for her ill friend's death.Season 2 premiere, 10 p.m., Syfy
Sanctuary
In part one of the two-part season opener, the group is still searching for Ashley (Emilie Ullerup) -- and they encounter a con artist along the way.
Also on the airwaves ...
Ghost Whisperer, 8 p.m., CBS
Law and Order, 8 p.m., NBC
Smallville, 8 p.m., CW
Star Wars: The Clone Wars, 8 p.m., CARTOON
'Til Death, 8:30 p.m., FOX
Ben 10: Alien Force, 8:30 p.m., CARTOON
Dollhouse, 9 p.m., FOX
Monk, 9 p.m., USA
Stargate Universe, 9 p.m., Syfy
Numb3rs, 10 p.m., CBS
The Soup, 10 p.m., E!
Psych, 10 p.m., USA
SATURDAY, OCTOBER 10
Season 6 premiere, 7 p.m., BBC America
The Graham Norton Show
Graham Norton opens his sixth season of awkward celebrity encounters with the Osbournes, Olivia Newton-John and Ricky Gervais.10 p.m., HBO
I'ma Be Me
Get blunt with Wanda Sykes -- she's serving up another hilarious comedy special.
Also on the airwaves ...
Saturday Night Live, 11:30 p.m., NBC
SUNDAY, OCTOBER 11
9 p.m., ABC
Desperate Housewives
Jesse Metcalfe is back! See what happens when Gabrielle (Eva Longoria Parker) and John the gardener reunite after several years apart.9 p.m., FOX
Family Guy
Chevy Chase and Dan Aykroyd lend their voices to spies who take over Cleveland's old house.Season 6 premiere, 10 p.m., E!
The Girls Next Door
Hef's got a few new girlfriends! Meet Crystal Harris and twins Karissa and Kristina Shannon.
Also on the airwaves ...
America's Funniest Home Videos, 7 p.m., ABC
Extreme Makeover: Home Edition, 8 p.m., ABC
The Amazing Race, 8 p.m., CBS
The Simpsons, 8 p.m., FOX
Food Network Challenge, 8 p.m., FOOD
The Cleveland Show, 8:30 p.m., FOX
Three Rivers, 9 p.m., CBS
The Next Iron Chef, 9 p.m., FOOD
Curb Your Enthusiasm, 9 p.m., HBO
Dexter, 9 p.m., SHO
American Dad!, 9:30 p.m., FOX
Bored To Death, 9:30 p.m., HBO
Brothers and Sisters, 10 p.m., ABC
Cold Case, 10 p.m., CBS
Mad Men, 10 p.m., AMC
Iron Chef America, 10 p.m., FOOD
Californication, 10 p.m., HBO
What are you watching tonight?
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