Bobbi and Hunter follow Gideon to a compound in Russia, and discover what he has in mind for the Inhumans in Russia.
President Ellis sponsors an international symposium on the Inhuman problem, and Coulson and Talbot must attend it. Along the way, they try to find Malick's inside man. Meanwhile, a foe from the past makes a return, and the team find a potential vaccine against Terrigenesis.moreless
Coulson and President Ellis come to an arrangement, and Coulson begins the hunt for Malick. Meanwhile, Daisy leads a team to Bogota to track down a rogue Inhuman, and discovers that there's more involved than they first thought.moreless
On the alien planet, Coulson hunts down Grant to get revenge for Rosalind's death. Meanwhile on Earth, the team secure the portal in the hopes of bringing their comrades home.
Coulson swears to do whatever it takes to bring in Grant, after the rogue agent strikes at someone close to Coulson. Meanwhile, Gideon captures Jemma and Fitz, and Mack convinces Joey and Lincoln to join the new team of Inhumans.moreless
While Coulson's team infiltrate the ATCU base, Coulson interrogates Rosalind about what they discover during the break-in. Meanwhile, Gideon explains to Grant the true origins of Hydra.
While Fitz helps Jemma recover the information from her phone that could help the team open the portal, Coulson and Rosalind join forces to track down Andrew after Lincoln comes in out of the cold to confirm that Andrew is Lash.moreless
Coulson accompanies Rosalind to the ATCU facility, while Daisy, Mack, and Lance run surveillance on Banks. Meanwhile, Melinda takes Bobbi with her to track down the man who attacked Andrew.
While Coulson and Rosalind launch their first joint operation to find Lash, Melinda worries that Lance is too invested in his attempts to kill Grant.
While Mack and Daisy try to get to Lincoln before the ACTU does, Lance and Melinda try to get close to Grant. Meanwhile, Fitz nurses Jemma back to health after her rescue.
The team turns to Elliott for help figuring out where the monolith took Jemma, and he leads them to a castle in Gloucestershire. Meanwhile, Lance prepares to hunt down Grant and turns to Melinda for help.moreless
While Fitz tries to get Jemma back, Coulson and Skye discover that another organization is also hunting Inhumans.
Coulson realizes that Jiaying intends to set off a war, but tries to avoid launching a counter attack for fear of hurting Skye. Meanwhile, Skye appeals to Jiaying to reconsider, and Grant tries to give Kara closure.moreless
Coulson leads an assault on the captured helicarrier, taking Cal along with them. Meanwhile, Jiaying prepares to unleash the Terrigen crystals on the world, and Skye is forced to confront her mother.
Tensions rise between S.H.I.E.L.D. and the Inhumans, with Skye caught in the middle. Meanwhile, Coulson reveals what he's been doing with the missing millions.
Coulson and Gonzales are forced to join forces with an unreliable ally to defeat Hydra.
While Skye questions her future with the Inhumans, Melinda must decide her future in the war between the two sides of S.H.I.E.L.D.
While Skye meets a fellow "Inhuman," Coulson takes on Gonzales for the future of S.H.I.E.L.D.
Skye must make a decision about her powers, while Coulson finds himself going up against... S.H.I.E.L.D.
The team deals with the revelation of Skye's altered nature, while Bobbi and Mack tell Lance where their true allegiance lie. Meanwhile, Grant and Agent 33 go on a personal mission.
To expose S.H.I.E.L.D.'s supposed crimes to the world, Cal gathers a team of "super-villains" and lures Coulson back to his hometown. Meanwhile, Melinda brings in her ex-husband to help evaluate Skye's psychological condition after her recent transformation.moreless
After a battle, Lady Sif finds herself on Earth with amnesia, and turns to S.H.I.E.L.D. for help. Meanwhile, Bobbi and Mack continue their own operation within the team, risking exposure.
While Jemma secures the Kree city, Skye is put into quarantine. Meanwhile the team carries out an operation against Hydra to eliminate the people who arranged Trip's death.
Coulson and his team prepare to destroy the Kree city, but learn where Whitehall and his people are drilling in and go to take them on. Meanwhile, Skye meets her father for the first time, and he reveals his plan to get revenge on Whitehall for killing Skye's mother.moreless
Coulson and half of the team head to San Juan to enter the Kree city, while the other half go to Vancouver to keep Raina from falling into Hydra's hands. However, Grant is one step ahead of them.moreless
While Coulson's team tries to track down the secret, they meet the Doctor. Meanwhile, Bobbi interrogates Sunil and Ward kidnaps his older brother.
Someone is killing people and leaving the alien writing etched on the corpses. As Coulson's team pursues the murderer, they discover a connection to their director's past.