With DE Michael Strahan's retirement in 2008, Toomer becomes the longest-tenured active New York Giant going into his 13th year since being drafted by the Giants.
On April 30, 2008, Toomer joined 39 other players from the Super Bowl champion New York Giants team on a trip to the White House, where the team was invited and honored by President George W. Bush in a ceremony held on the south lawn. Toomer presented a Giants jersey bearing the name "Bush" and number 43 to the 43rd president of the United States at the ceremony.
Amani Toomer(on his expectations from training camp): I thought our team had a great shot. We were all really familiar with the offense. Kevin Gilbride being our offensive coordinator gave our offense a new look and our new defensive coordinator got me really excited. Once I saw us practicing and I saw the way things were going, how Eli was playing, I just felt like we had a really good shot. I felt like we had a lot of talent on the field. Not just talent but we had everybody who was in the positions to show their talent had been on our team before so they were a little more familiar with our system.
Amani Toomer(on facing the Green Bay Packers in the NFC Championship Game): They're not going to face the same team they faced in Week 2. We've got a lot of momentum. And let's take it all the way to Green Bay.
Amani Toomer(on the Giants' victory over the Cowboys in the 2008 Divisional playoff game): When we got off to that good start, it kind of let everybody know that we came to play. We were not here to lay down and roll over for anybody. That's kind of the M.O. of our team.