Andrew is the chairman of the National Leadership Group of White Ribbon Day, a day to help stop violence against women.
Along with Rebecca De Unamuno, a good friend, Andrew won the 'Improv World Championships' in Canada.
As of 2007, Andrew has been nominated for two Logie Awards in his career. They were for 'Best New Male Talent' and 'Most Popular Presenter'.
Andrew co-hosted both the 2005 TV Week Logie Awards, the Australian version of the Emmy's, and Australia Unites, a televised fundraiser for Asia shortly after the 2004 tsunami, with Eddie McGuire and Rove McManus.
Andrew previously worked with a Sydney law firm as a property lawyer. This ended after he realized his ongoing passion for acting and presenting.
In his adolescence, Andrew was very actively involved with theatre sports.
Andrew attended St Ignatius' College, Riverview.
Andrew confesses that he loves to shop for women's clothes for his wife.
Andrew and wife, Eleanor, have two children: Barnaby James and Rory Ignatius.
Andrew describes himself as a 'people person'. His biggest ambition for the future is acting in movies.
Andrew's father is prominent Sydney judge, Barry O'Keefe. His mother is Jan O'Keefe. Andrew is the fourth of five children.
Andrew is the nephew of the legendary music icon Johnny O'Keefe. Just like his uncle, Andrew is a very talented singer and has sung on various Channel 7 events and at the TV Week Logie Awards.
Andrew: (where he sees himself in 10 years) I have, presumably, another 35 years left of my working career, and in that time I'd love to host other styles of shows, I'd love to act, perform and produce music, sit on the boards of arts foundations…
Andrew: (on balancing work and his family life) It's tricky! I live in Sydney but film predominantly in Melbourne, on average three days a fortnight. I have friends who work in banks and law firms who leave their homes at 7am and they're not back until 7pm. I see my family all day, half the time, and we get to spend a lot of special time together.
Andrew: I was in a bar before Christmas, chatting on the phone - to my dearest friend who lives in England - and this drunk kept butting saying, "I've got to talk to you about Deal." I said, "Give me five minutes and I'll be with you". He walked off and didn't come back and I read in the paper the next morning, "Game-show grinch spoils Christmas for revellers".
Andrew: I have a skip-bin mind for trivia. I'm also one of those egotistical people ho thinks he knows everything.
Andrew: I don't want to be a 50-year-old game-show host.
Andrew: (talking about Deal or No Deal) People tell me it's very addictive and I am thinking of setting up a counselling group to help people get over it. They might have to watch endless repeats of The New Price is Right or something like that.
Andrew: (on what's normally on his desk) Generally, there's a half-eaten chocolate. Quite often, there's a bottle of wine sent from a fan or a network executive. There's a picture of Louis Armstrong and, currently - through no fault of my own - there seems to be a lingerie calendar.