After listening to Trudy's last message, Monk finally discovers who killed his wife. Racing against time before he dies of poison, he must make a fateful decision.
Upon being reinstated, Monk hopes to help track down a serial killer. However, he discovers that he is instead assigned to desk duty to ease himself back into his position. However, when the serial killer is caught, Monk begins to realize something is amiss.moreless
Sharona Fleming stops by to visit her former employer while dealing with the legal matters involving her uncle's accidental death, but Monk soon begins to suspect that the accident was anything but.
Monk is forced to attend Dr. Bell's group therapy sessions, and he begins to suspect that a murderer in the group might be going after the other patients.
Natalie suspects a theater critic is responsible for a murder, despite the fact that he was present to review her daughter Julie's play at the same time the victim died.
Monk and Natalie are stranded in a small desert town and the detective spots a UFO. He soon discovers himself the center of attention, and is called in to investigate a dead woman discovered in the desert.moreless
When Monk receives a gift of tickets to the playoff, Stottlemeyer is eager to go with him. However, Monk is more interested in a mystery outside the stadium: who tried to kill a fan?moreless
While investigating the theft of a bicycle from a biotech CEO, Monk is shot and ends up in a wheelchair... with Natalie as the person forced to wheel him around.
It's Christmas, and three homeless men ask Monk to solve the case of their dead friend. The trail leads to a monastery where a fountain has the miraculous power to cure anyone who drinks from it.moreless
Monk undergoes hypnotic therapy as treatment for his OCD. After a session, he adopts a more childlike personality.
Meanwhile a soon-to-be divorced woman disappears and a murder occurs.
As Monk and his friends watch a TV newsmagazine piece on the solution of his hundredth case, he realizes that one of the victims was murdered by a different killer.
A friend of Natalie's late husband comes to Monk asking for help when his friend supposedly commits suicide aboard a locked cabin on a submarine. Monk agrees to investigate, despite his phobia about being on--and beneath--the water.moreless