As a child, in the movie El Gran Triunfo in 1981, Vale portrayed the daughter of Mexican superstar, Rigo Tovar. Prior to the La fea más bella, she had not been considered for the role of a main character in any Mexican telenovela but had appeared in a number of Spanish language programs. As a comedian, Vale was one of the main celebrity impersonators in the comedy show La Parodia from 2000 to 2005. In 2005 and 2006 she performed in El privilegio de mandar. Telenovelas are wildly popular throughout the Spanish speaking world and their limited run series are very profitable. As of 2006, La fea más bella is the number one Univision TV program according to 2006 Nielsen ratings.
In April 2007, "People en espanol" announced that Vale would make a special guest appearance on "Ugly Betty", in which she'd reprise her Lety role in the episode "A Tree Grows In Guadalajara," but it turned out that she actually played a Lety look-alike named Angélica.