Raised in Sayville, New York, Sayre received her Bachelor of Arts in Theatre from Kutztown University. Upon graduating, the actress studied at both the William Esper Studio and with Betty Buckley at the T. Schriber Studio. Outside of theater, Sayre scored principal roles on daytime television including Another World and All My Children. Her movie credits include MGM's feature film My Summer Story and the sequel to A Christmas Story.
In addition to working out and singing, Anne and her husband Tony enjoy hosting parties for friends at their Weehawken home. Her birthday is August 30. Anne and Tony recently had their first son, John Sayre Grimaldi, on May 3, 2004.