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Anthony married Stila cosmetics creator Jeanine Lobell on September 5, 1994. They met when she was the make-up artist on the set of a film he starred in, Pet Sematary II (1992). They have four children together: son Bailey (b. 1994) and daughters Esme (b. 1996), Wallis (b. 2000), and Poppy (b. 2002).
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While on ER, Anthony appeared in 6 of NBC's The More You Know public service announcements. His topics were arts education, parental involvement, school support, sexually transmitted diseases, reading, and teacher appreciation.
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According to trade reports released on August 4, 1998, Anthony signed a $35 million dollar pact with Warner Bros. to remain on
ER for four additional seasons (through 2002), making him the highest paid actor on a TV dramatic series at that time.
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Following his departure from
ER in 2002, reportedly to spend more time with his family, Edwards moved his brood to Manhattan. He says he considers himself "smaller than life," and doesn't lead a lifestyle that keeps him on the cover of tabloids.
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For his portrayal of Dr. Mark Greene on
ER, Anthony was nominated for a Golden Globe Award for "Best Performance by an Actor in a Television Series - Drama" in 1996, 1997, 1998, and 1999. He won the award in 1998.
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Anthony's parents wouldn't allow him to watch prime-time TV as a teenager.
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Anthony is a big fan of race car driving.
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Anthony and his family spend every Thanksgiving with
Helen Hunt.
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In his youth, Anthony collected James Taylor and Styx tapes.
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Anthony owns his own production company called Aviator Films.
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Anthony is on the Honorary Board of Directors for the Cure Autism Now Foundation.
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Anthony has a cat named Nitro.
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Anthony dated Meg Ryan for a period of time.
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Anthony went to school with and is very good friends with Eric Stoltz.
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Anthony is an honorary board member of Access Theatre, a repertory acting company comprised of disabled artists.
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Anthony was nominated for "Best Actor" by Cable Ace for his role in Sexual Healing.
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Anthony is 6'2".
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Anthony's nickname is Ace.
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Anthony is a big fan of race car driving and South Park.
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As teenagers in Santa Barbara, California, Anthony and childhood friend
Eric Stoltz studied ballet so that they could meet girls.
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For his portrayal of Dr. Mark Greene on
ER, Anthony was nominated for a Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Drama Series in 1996, 1997, 1998, 1999, and 2001 (for performances each respective previous year). He won the award in 1996 and 1998. He was nominated for Outstanding Performance by an Ensemble in a Drama Series for the show from 1997-2001. He won from 1997-1999.