The team goes undercover on the set of a superhero movie in Kazakhstan to dismantle a nuclear missile being sold by terrorists.
Tensions rise between S.H.I.E.L.D. and the Inhumans, with Skye caught in the middle. Meanwhile, Coulson reveals what he's been doing with the missing millions.
Amelia's past addictions don't stay hidden and result in trouble for her at work. Meanwhile, Jo performs her first solo surgery; Arizona must make a tough call when Dr. Herman is away; and a couple who were caught in a fire arrive at the ER.moreless
Jemma puts her cover as a researcher for Hydra at risk to stop her new organization from acquiring Donnie Gill, a Gifted who could prove valuable to both sides. Meanwhile, Fitz confronts Grant for the first time since Grant tried to kill him.moreless
Scorpion is called in to save the Governor's daughter when she is somehow "bio-hacked" with a deadly virus and is given 24 hours to live. A letter about his sister, gives the case new meaning for Walter.moreless
Garrett and Triplett return to help track down the Clairvoyant, who sends Deathlok to stop them.
As Coulson tries to save Skye, he teams up with Ward's former SO, John Garrett.
April’s sisters arrive to help celebrate April’s upcoming nuptials and quickly get on her nerves. Matthew and Jackson are forced to work together when they witness a terrible accident, Callie and Arizona work hard to reestablish their relationship and Cristina is pressured to live stream an upcoming surgery. Meanwhile, a familiar face returns to the hospital.moreless
Grant and Fitz are sent on a suicide mission, and Coulson desperately works to save their lives from within S.H.I.E.L.D.
As Daniel's attention is directed elsewhere, roadblocks mount for Emily. Two people start turning on Emily.
Joss attempts to help Olivier impress new clients and April tells Richard how frustrated she was when Paul appeared at Lucy's school. Meanwhile, Savi finally faces up to reality, her and Harry are probably over.moreless
Bailey finds herself at the center of a CDC investigation surrounding the death of several of her patients, as Jackson and the rest of the board members argue over how to address the crisis with the public. Meanwhile, Cristina teases Alex about his unspoken feelings for Jo, and Owen continues to take special care of Ethan as the condition of his parents remains uncertain.moreless
Cat and Vincent wonder if Alex can be trusted to keep the secret of Vincent's past. Evan discovers that Claire, the woman he is dating, has been keeping secrets from him. Heather meets Joe's younger brother, Darius, and develops feelings for him. Vincent tries to win over Cat with romantic gestures for Valentine's Day.moreless
Conrad and Victoria choose to take on the press by planning an elaborate ceremony to renew their wedding vows, but the event ends badly, placing Conrad in an undesirable position with Americon Initiative. Meanwhile, Nolan's company is in jeopardy, and Padma's potential involvement remains unclear. Also, Emily coaches Amanda on how to handle Mason's increasing questions, but he continues to dig for the information he really wants.moreless
An inmate goes off the rails after receiving damning medical news.
Ethan's friends attempt to prove his innocence after he is arrested for murder.
Emily's plot further unravels as Victoria's unstable relationship with her family grows increasingly more tense when an unwanted pawn in Emily's game heads to the Hamptons with questionable intentions. Meanwhile, Lydia's memory is a growing concern for the Graysons and a recently embittered friend begins to play dirty.moreless
While trying to solve the murder of a police chief Lisbon runs into her brother Tommy, a bounty hunter, who's tracking a bail jumper.
The General works to regain Scylla.
T-Bag gets a new partner.
Michael and Lincoln have an important meeting.