After Brooke appeared on "The Oprah Winfrey Show" to discuss her battles with postpartum depression after the birth of her daughter Rowan, former co-star Tom Cruise, publicly criticized her for promoting the use of the drug Paxil and for using the drug herself to overcome her depression. Tom's comments were based on his beliefs as a Scientologist. Scientology is publicly and vehemently opposed to psychiatry and psychology.
Brooke responded to Cruise's statements publicly, stating that his comments were "irresponsible" and "dangerous." She encouraged Tom to "stick to fighting aliens", which most believe to be a reference to his starring role in the film War Of The Worlds, but also to the teachings of Scientology and their belief in the alien being "Xenu". Brooke also published an essay in "The New York Times" on July 1, 2005, to further respond to Cruise's attack. In the article she explained that it was up to mothers to decide the best course of treatment for postpartum depression.